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Article

Investigating models of protein function and allostery with a widespread mutational analysis of a light-activated protein.

Biophysical journal - 20 Aug 2013

Zayner Josiah P, Antoniou Chloe, French Alexander R, Hause Ronald J, Sosnick Tobin R

Abstract excerpt

To investigate the relationship between a protein's sequence and its biophysical properties, we studied the effects of more than 100 mutations in Avena sativa light-oxygen-voltage domain 2, a model protein of the Per-Arnt-Sim family. The A. sativa light-oxygen-voltage domain 2 undergoes a photocycle with a conformational change involving the unfolding of the terminal helices. Whereas selection studies typically...

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Identifiers

PMID: 23972854
DOI: 10.1016/j.bpj.2013.07.010
PMCID: PMC3752136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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