Inactive type II and type I receptors for TGF beta are dominant inhibitors of TGF beta-dependent transcription.

doi:10.1074/jbc.270.14.8274

Back to search

Article

Inactive type II and type I receptors for TGF beta are dominant inhibitors of TGF beta-dependent transcription.

The Journal of biological chemistry - 7 Apr 1995

Brand T, Schneider M D

Abstract excerpt

Although transforming growth factor-beta (TGF beta) is implicated in differentiation and disease, proof of in vivo function requires specific inhibitors of the TGF beta cascade. TGF beta binds a family of type I and type II receptors (T beta RI, T beta RII), containing a cytoplasmic serine/threon...

Topics

Animals
Base Sequence
Cell Line
Mink
Molecular Sequence Data
Phenotype
Phosphotransferases
Point Mutation
Receptors, Transforming Growth Factor beta
Sequence Deletion
Signal Transduction
Transcription, Genetic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.