Article
Lack of association between BRAF V600E mutation and mitogen-activated protein kinase activation in papillary thyroid carcinoma.
Pathology international - 1 Jan 2007
Zuo Hui, Nakamura Yasushi, Yasuoka Hironao, Zhang Ping, Nakamura Misa, Mori Ichiro, Miyauchi Akira, Kakudo Kennichi
Abstract excerpt
The BRAF V600E mutation has been identified in a high proportion of papillary thyroid carcinoma (PTC). In cell lines and a transgenic mouse model it has been demonstrated that the mutation constitutively activates the mitogen-activated protein kinase (MAPK) pathway but in human PTC samples its effects remain unexamined. Herein the correlation of BRAF mutation and MAPK activation was examined in 42 human PTC...
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