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The TβRI promotes migration and metastasis through thrombospondin 1 and ITGAV in prostate cancer cells

20 Sept 2024

Abstract excerpt

TGFβ potently modifies the extracellular matrix (ECM), which is thought to favor tumor cell invasion. However, the mechanism whereby the cancer cells employ the ECM proteins to facilitate their motility is largely unknown. In this study we used RNA-seq and proteomic analysis to examine the proteins secreted by castration-resistant prostate cancer (CRPC) cells upon TGFβ treatment and found that thrombospondin 1...

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PMID: 39304722
DOI: 10.1038/s41388-024-03165-3

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