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Article

Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture.

Journal of proteomics - 8 Oct 2013

Rivera-Torres José, Acín-Perez Rebeca, Cabezas-Sánchez Pablo, Osorio Fernando G, Gonzalez-Gómez Cristina, Megias Diego, Cámara Carmen, López-Otín Carlos, Enríquez José Antonio, Luque-García José L, Andrés Vicente

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) is a rare segmental premature aging disorder that recapitulates some biological and physical aspects of physiological aging. The disease is caused by a sporadic dominant mutation in the LMNA gene that leads to the expression of progerin, a mutant form o...

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Source

Identifiers

PMID: 23969228
DOI: 10.1016/j.jprot.2013.08.008

Genes

LMNA

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23969228-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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