Article
Clinical course of genetic diseases of the insulin receptor (type A and Rabson-Mendenhall syndromes): a 30-year prospective.
Medicine - 1 Jul 2004
Musso Carla, Cochran Elaine, Moran Stephanie Ann, Skarulis Monica C, Oral Elif Arioglu, Taylor Simeon, Gorden Phillip
Abstract excerpt
The interaction of insulin with its cell surface receptor is the first step in insulin action and the first identified target of insulin resistance. The insulin resistance in several syndromic forms of extreme insulin resistance has been shown to be caused by mutations in the receptor gene. We studied 8 female patients with the type A form of extreme insulin resistance and 3 patients (2 male and 1 female) with...
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