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Article

Successful rhIGF1 treatment for over 5 years in a patient with severe insulin resistance due to homozygous insulin receptor mutation.

Diabetic medicine : a journal of the British Diabetic Association - 1 Mar 2016

Carmody D, Ladsaria S S, Buikema R K, Semple R K, Greeley S A W

Abstract excerpt

BACKGROUND: Congenital insulin resistance syndromes are caused by biallelic mutations within the insulin receptor gene (INSR). Recombinant human insulin-like growth factor (rhIGF1) has been used with mixed success; however, rigorous assessment of its efficacy is lacking. Here, we describe a child with a homozygous mutation in INSR successfully treated with rhIGF1 for more than 5 years. CASE REPORT: The patient...

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Source

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Identifiers

PMID: 26262567
DOI: 10.1111/dme.12884
PMCID: PMC4751063

Genes

INSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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