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Article

copy number variation analysis in familial BRCA1/2-negative Finnish breast and ovarian cancer.

PloS one - 1 Jan 2013

Kuusisto Kirsi M, Akinrinade Oyediran, Vihinen Mauno, Kankuri-Tammilehto Minna, Laasanen Satu-Leena, Schleutker Johanna

Abstract excerpt

BACKGROUND: Inherited factors predisposing individuals to breast and ovarian cancer are largely unidentified in a majority of families with hereditary breast and ovarian cancer (HBOC). We aimed to identify germline copy number variations (CNVs) contributing to HBOC susceptibility in the Finnish population. METHODS: A cohort of 84 HBOC individuals (negative for BRCA1/2-founder mutations and pre-screened for the...

Topics

Adult
Aged
Case-Control Studies
DNA Copy Number Variations
Female
Finland
Gene Deletion
Gene Duplication
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Germ-Line Mutation

Hereditary Breast and Ovarian Cancer Syndrome

Humans

Middle Aged

Pedigree

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 23967248
DOI: 10.1371/journal.pone.0071802
PMCID: PMC3742470

Genes

BRCA1
EPHA3
CSMD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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