Copy number variants in BRCA1 and BRCA2 genes in Polish patients with breast and ovarian cancer.

doi:10.1007/s00432-026-06527-4

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Copy number variants in BRCA1 and BRCA2 genes in Polish patients with breast and ovarian cancer.

Journal of cancer research and clinical oncology - 23 Jun 2026

Doraczynska-Kowalik Anna, Matkowski Rafal, Michalowska Dagmara, Chrusciel Agnieszka, Semeniuk Mariola, Blomka Dorota, Lawicka Paulina, Czykalko Ewelina, Abrahamowska Mariola, Pietron Aleksandra, Janus-Szymanska Gabriela, Pawlak Ireneusz, Maciejczyk Adam, Szelachowska Jolanta, Laczmanska Izabela

Abstract excerpt

PURPOSE: BRCA1 and BRCA2 are key susceptibility genes in hereditary breast and ovarian cancer (HBOC), with mutational status guiding PARP inhibitor therapy. While single-nucleotide variants (SNVs) predominate, the prevalence of copy number variants (CNVs) varies significantly across different populations. This study aims to determine the incidence of BRCA1/2 CNVs in the Polish population, where data remain scarce...

Read the complete abstract on PubMed

Topics

Humans
Female
Poland
Middle Aged
Ovarian Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Breast Neoplasms

DNA Copy Number Variations

Retrospective Studies

Adult

Aged

Genetic Predisposition to Disease

BRCA1 Protein

BRCA2 Protein

Genes, BRCA2

Source

Open in PubMed Open full text

Identifiers

PMID: 42334620
DOI: 10.1007/s00432-026-06527-4
PMCID: PMC13547560

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Copy number variants in BRCA1 and BRCA2 genes in Polish patients with breast and ovarian cancer.PMID 42334620Read ↗

Copy number variants in BRCA1 and BRCA2 genes in Polish patients with breast and ovarian cancerSemantic proximity Read ↗

Germline BRCA1/2 Variants in Polish Patients with Family History of Breast and Ovarian Cancer: Prevalence, CNV Detection, and Identification of a Novel Loss-of-Function Mutation.Semantic proximity Read ↗

Germline copy number variations in BRCA1/2 negative families: Role in the molecular etiology of hereditary breast cancer in Tunisia.Semantic proximity Read ↗

Rare copy number variants (CNVs) and breast cancer riskSemantic proximity Read ↗

Rare Copy Number Variants (CNVs) and Breast Cancer RiskSemantic proximity Read ↗

copy number variation analysis in familial BRCA1/2-negative Finnish breast and ovarian cancer.Semantic proximity Read ↗

New recurrent BRCA1/2 mutations in Polish patients with familial breast/ovarian cancer detected by next generation sequencing.Semantic proximity Read ↗

New Germinal Mutation of BRCA1 gene (c.829_832delAATA) in a Polish Patient with Breast/Ovarian CancerSemantic proximity Read ↗

Prevalence of recurrent and non-recurrent BRCA1 and BRCA2 pathogenic variants in Polish breast cancer patients: insights from a regional genetic testing cohort from Lower Silesia.Semantic proximity Read ↗

Spectrum of germline pathogenic variants in Brazilian hereditary breast/ovarian cancer cases.Semantic proximity Read ↗

Extended genetic analysis and tumor characteristics in over 4600 women with suspected hereditary breast and ovarian cancer.Semantic proximity Read ↗

Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.