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Screening of BRCA1/2 genes mutations and copy number variations in patients with high risk for hereditary breast and ovarian cancer syndrome (HBOC).

BMC cancer - 10 Aug 2020

El Ansari Fatima Zahra, Jouali Farah, Marchoudi Nabila, Bennani Mohcine Mechita, Ghailani Naima Nourouti, Barakat Amina, Fekkak Jamal

Abstract excerpt

BACKGROUND: Hereditary breast and ovarian cancer (HBOC) is an autosomal dominant inherited cancer susceptibility disorder. Both BRCA1 and BRCA2 genes are considered as high penetrance genes of this syndrome. The identification of BRCA1/2 genetic alterations before cancer development, grant patients the chance to benefit from various medical cancer prevention approaches. Therefore, the appearance of recent...

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Identifiers

PMID: 32778078
DOI: 10.1186/s12885-020-07250-0
PMCID: PMC7418307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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