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Article

Vitamin E δ-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer.

Cancer prevention research (Philadelphia, Pa.) - 1 Oct 2013

Husain Kazim, Centeno Barbara A, Chen Dung-Tsa, Hingorani Sunil R, Sebti Said M, Malafa Mokenge P

Abstract excerpt

Previous work has shown that vitamin E δ-tocotrienol (VEDT) prolongs survival and delays progression of pancreatic cancer in the LSL-Kras(G12D)(/+);Pdx-1-Cre mouse model of pancreatic cancer. However, the effect of VEDT alone or in combination with gemcitabine in the more aggressive LSL-Kras(G12D)(/+);LSL-Trp53(R172H)(/+);Pdx-1-Cre (KPC) mouse model is unknown. Here, we studied the effects of VEDT and the...

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Identifiers

PMID: 23963802
DOI: 10.1158/1940-6207.CAPR-13-0157
PMCID: PMC4165552

Genes

PARP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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