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Article

Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II.

The Journal of cell biology - 2 May 2011

Zhang He, Niu Beibei, Hu Ji-Fan, Ge Shengfang, Wang Haibo, Li Tao, Ling Jianqun, Steelman Brandon N, Qian Guanxiang, Hoffman Andrew R

Abstract excerpt

Monoallelic expression of IGF2 is regulated by CCCTC binding factor (CTCF) binding to the imprinting control region (ICR) on the maternal allele, with subsequent formation of an intrachromosomal loop to the promoter region. The N-terminal domain of CTCF interacts with SUZ12, part of the polycomb...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21536749
DOI: 10.1083/jcb.201101021
PMCID: PMC3087012

Genes

CTCF
IGF2
SUZ12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21536749-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II.PMID 21536749Read ↗

CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop.Semantic proximity Read ↗

Restoration of IGF2 imprinting by polycomb repressive complex 2 docking factor SUZ12 in colon cancer cells.Semantic proximity Read ↗

Promoter histone H3K27 methylation in the control of IGF2 imprinting in human tumor cell lines.Semantic proximity Read ↗

More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domainSemantic proximity Read ↗

CTCF binding at the <i>H19</i> imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to <i>Igf2</i>Semantic proximity Read ↗

Locus-Specific and Stable DNA Demethylation at the H19/IGF2 ICR1 by Epigenome Editing Using a dCas9-SunTag System and the Catalytic Domain of TET1.Semantic proximity Read ↗

CTCF binding at the insulin-like growth factor-II (IGF2)/H19 imprinting control region is insufficient to regulate IGF2/H19 expression in human tissues.Semantic proximity Read ↗

The molecular function and clinical phenotype of partial deletions of the IGF2/H19 imprinting control region depends on the spatial arrangement of the remaining CTCF-binding sites.Semantic proximity Read ↗

CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region.Semantic proximity Read ↗

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 geneSemantic proximity Read ↗

A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele.Semantic proximity Read ↗

Role of CTCF binding sites in the Igf2/H19 imprinting control region.Semantic proximity Read ↗

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