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Article

Application of the concept synthetic lethality toward anticancer therapy: a promise fulfilled?

Cancer letters - 28 Sept 2014

Canaani Dan

Abstract excerpt

Back in 1997, a suggestion to apply the concept of synthetic lethality towards the development of selective, less toxic, cancer drugs and anticancer targets, was brought forward. The availability of large scale synthetic, low-molecular-weight chemical libraries seemed to lend itself to the concept. Human/mouse genome-wide siRNAs and shRNA-expressing libraries allowing high throughput screening for target genes...

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PMID: 23962561
DOI: 10.1016/j.canlet.2013.08.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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