Article
Synthetic lethality to overcome cancer drug resistance.
Current medicinal chemistry - 1 Jan 2012
Porcelli L, Quatrale A E, Mantuano P, Silvestris N, Brunetti A E, Calvert H, Paradiso A, Azzariti A
Abstract excerpt
A large body of evidence point out that the onset of synthetic lethality may provide a useful tool for amplifying the efficacy of drugs in anticancer regimens, to uncover interdependence between genes and to identify predictive factors that would be extremely useful to guide in the selection of more effective targeted drugs and drug combinations for each patient. Here, we provide an overview on the exploitation...
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