Article
β2-Adrenoceptor agonists in the regulation of mitochondrial biogenesis.
Bioorganic & medicinal chemistry letters - 1 Oct 2013
Peterson Yuri K, Cameron Robert B, Wills Lauren P, Trager Richard E, Lindsey Chris C, Beeson Craig C, Schnellmann Rick G
Abstract excerpt
The stimulation of mitochondrial biogenesis (MB) via cell surface G-protein coupled receptors is a promising strategy for cell repair and regeneration. Here we report the specificity and chemical rationale of a panel of β2-adrenoceptor agonists with regards to MB. Using primary cultures of renal cells, a diverse panel of β2-adrenoceptor agonists elicited three distinct phenotypes: full MB, partial MB, and non-MB....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.