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Article

The Tudor domain of the PHD finger protein 1 is a dual reader of lysine trimethylation at lysine 36 of histone H3 and lysine 27 of histone variant H3t.

Journal of molecular biology - 17 Apr 2014

Kycia Ina, Kudithipudi Srikanth, Tamas Raluca, Kungulovski Goran, Dhayalan Arunkumar, Jeltsch Albert

Abstract excerpt

PHF1 associates with the Polycomb repressive complex 2 and it was demonstrated to stimulate its H3K27-trimethylation activity. We studied the interaction of the PHF1 Tudor domain with modified histone peptides and found that it recognizes H3K36me3 and H3tK27me3 (on the histone variant H3t) and that it uses the same trimethyllysine binding pocket for the interaction with both peptides. Since both peptide sequences...

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Source

Identifiers

PMID: 23954330
DOI: 10.1016/j.jmb.2013.08.009

Genes

PHF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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