Article

Orphan nuclear receptors recruit TRIM28 to promote telomeric H3K9me3 for the alternative lengthening of telomeres pathway

2025-06-19

Abstract excerpt

Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism deployed in embryonic stem cells and cancer cells. High levels of the heterochromatin mark H3 lysine 9 trimethylation (H3K9me3) at telomeres are critical for ALT, but how that is achieved remains unclear. Telomeric association of orphan nuclear receptors (NRs)—such as COUP-TF1, COUP-TF2, TR2, and TR4—has been shown previously to promote...

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Literature Corpus work: 8e3eff42-2d3d-5d0e-b2ad-6e544e567435
DOI: 10.1101/2025.06.16.658187

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