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Article

Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo.

Molecular and cellular biology - 1 Mar 2006

Bhakat Kishor K, Mokkapati Sanath K, Boldogh Istvan, Hazra Tapas K, Mitra Sankar

Abstract excerpt

The human 8-oxoguanine-DNA glycosylase 1 (OGG1) is the major DNA glycosylase responsible for repair of 7,8-dihydro-8-oxoguanine (8-oxoG) and ring-opened fapyguanine, critical mutagenic DNA lesions that are induced by reactive oxygen species. Here we show that OGG1 is acetylated by p300 in vivo predominantly at Lys338/Lys341. About 20% of OGG1 is present in acetylated form in HeLa cells. Acetylation significantly...

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Identifiers

PMID: 16478987
DOI: 10.1128/MCB.26.5.1654-1665.2006
PMCID: PMC1430230

Genes

OGG1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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