Article
Suppression mechanism of the calcium sensitivity in Saccharomyces cerevisiae ptp2Δmsg5Δ double disruptant involves a novel HOG-independent function of Ssk2, transcription factor Msn2 and the protein kinase A component Bcy1.
Journal of bioscience and bioengineering - 1 Feb 2014
Laviña Walter A, Shahsavarani Hosein, Saidi Abbas, Sugiyama Minetaka, Kaneko Yoshinobu, Harashima Satoshi
Abstract excerpt
In Saccharomyces cerevisiae, disruption of both protein phosphatase genes, PTP2 and MSG5, causes calcium sensitivity while additional disruption of protein kinase genes BCK1, MKK1, SLT2, MCK1, YAK1 and SSK2 confers calcium tolerance. Although the roles of BCK1, MKK1 and SLT2 have been characteriz...
Topics
- Calcium Signaling
- Cyclic AMP-Dependent Protein Kinases
- DNA-Binding Proteins
- Enzyme Activation
- Gene Deletion
- Gene Expression Regulation, Fungal
- Glycerol
- MAP Kinase Kinase Kinases
- Osmolar Concentration
- Phenotype
- Protein Tyrosine Phosphatases
- Saccharomyces cerevisiae