Article
Integrated genotypic analysis of hedgehog-related genes identifies subgroups of keratocystic odontogenic tumor with distinct clinicopathological features.
PloS one - 1 Jan 2013
Shimada Yasuyuki, Katsube Ken-ichi, Kabasawa Yuji, Morita Kei-ichi, Omura Ken, Yamaguchi Akira, Sakamoto Kei
Abstract excerpt
Keratocystic odontogenic tumor (KCOT) arises as part of Gorlin syndrome (GS) or as a sporadic lesion. Gene mutations and loss of heterozygosity (LOH) of the hedgehog receptor PTCH1 plays an essential role in the pathogenesis of KCOT. However, some KCOT cases lack evidence for gene alteration of PTCH1, suggesting that other genes in the hedgehog pathway may be affected. PTCH2 and SUFU participate in the occurrence...
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