Article
Severe obesity as an oligogenic condition: evidence from 1714 adults seeking treatment in the UK National Health Service.
Human genomics - 19 Dec 2025
Almansoori Sumaya, Amin Hasnat A, Alsters Suzanne I, Handley Dale, Yiorkas Andrianos M, Hashim Nikman Adli Nor, Ramzi Nurul Hanis, Bonanomi Gianluca, Small Peter, Purkayastha Sanjay, van Haelst Mieke, Walters Robin G, le Roux Carel W, Chahal Harvinder S, Drenos Fotios, Blakemore Alexandra If
Abstract excerpt
Previous evidence has established genetics as an important contributing factor to severe (class III) obesity, which is a chronic, relapsing condition, with a high burden of comorbidity and mortality. We therefore designed a custom genotyping array to screen a cohort of UK patients seeking treatment for severe obesity in a cost-effective way. A total of 1,714 participants were genotyped using a custom AXIOM array,...
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