Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hyperthermia inhibits homologous recombination repair and sensitizes cells to ionizing radiation in a time- and temperature-dependent manner.

Journal of cellular physiology - 1 Jul 2013

Genet Stefan C, Fujii Yoshihiro, Maeda Junko, Kaneko Masami, Genet Matthew D, Miyagawa Kiyoshi, Kato Takamitsu A

Abstract excerpt

Hyperthermia has long been known as a radio-sensitizing agent that displays anti-tumor effects, and has been developed as a therapeutic application. The mechanisms of hyperthermia-induced radio-sensitization are highly associated with inhibition of DNA repair. Our investigations aimed to show how hyperthermia inactivate homologous recombination repair in the process of sensitizing cells to ionizing radiation by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to CHO Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cricetulus

Share to DNA Breaks, Double-Stranded

Share to Histones

Share to Rad51 Recombinase

Share to Radiation Tolerance

Share to Recombinational DNA Repair

Source

Identifiers

PMID: 23254360
DOI: 10.1002/jcp.24302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyperthermia inhibits homologous recombination repair and sensitizes cells to ionizing radiation in a time- and temperature-dependent manner.PMID 23254360Read ↗

Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategiesSemantic proximity Read ↗

Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them allSemantic proximity Read ↗

Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatmentSemantic proximity Read ↗

Hyperthermic radiosensitization: mode of action and clinical relevanceSemantic proximity Read ↗

Modification of radiation-induced damage by hyperthermia--role of repair processes.Semantic proximity Read ↗

Radiosensitization by Hyperthermia: The Effects of Temperature, Sequence, and Time Interval in Cervical Cell LinesSemantic proximity Read ↗

A DNA double-strand break repair-deficient mutant of CHO cells shows reduced radiosensitization after exposure to hyperthermic temperatures in the plateau phase of growth.Semantic proximity Read ↗

Effects of hyperthermia on the repair of radiation-induced DNA single- and double-strand breaks in DNA double-strand break repair-deficient and repair-proficient cell lines.Semantic proximity Read ↗

Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell linesSemantic proximity Read ↗

Enhancing radiosensitisation of BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-iSemantic proximity Read ↗

Mechanism of radiosensitization by hyperthermia (> or = 43 degrees C) as derived from studies with DNA repair defective mutant cell lines.Semantic proximity Read ↗

Effect of therapies-mediated modulation of telomere and/or telomerase on cancer cells radiosensitivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.