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Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: effects of saccharin preference, impulsivity, and sex.

Physiology & behavior - 2 Oct 2013

Holtz Nathan A, Anker Justin J, Regier Paul S, Claxton Alex, Carroll Marilyn E

Abstract excerpt

A key feature of substance use disorders is continued drug consumption despite aversive consequences. This has been modeled in the animal laboratory by pairing drug self-administration with electric shock, thereby punishing drug intake (Deroche-Gamonet et al. 2004). In the present experiments, we examined the effects of punishment on i.v. cocaine self-administration by adding histamine to the cocaine solution...

Topics

Animals
Behavior, Animal
Choice Behavior
Cocaine
Cocaine-Related Disorders
Female
Histamine
Impulsive Behavior
Male
Phenotype
Punishment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Rats, Sprague-Dawley

Saccharin

Self Administration

Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 23948673
DOI: 10.1016/j.physbeh.2013.08.004
PMCID: PMC4617530

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