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Article

Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: effects of saccharin preference, impulsivity, and sex.

Physiology & behavior - 2 Oct 2013

Holtz Nathan A, Anker Justin J, Regier Paul S, Claxton Alex, Carroll Marilyn E

Abstract excerpt

A key feature of substance use disorders is continued drug consumption despite aversive consequences. This has been modeled in the animal laboratory by pairing drug self-administration with electric shock, thereby punishing drug intake (Deroche-Gamonet et al. 2004). In the present experiments, we examined the effects of punishment on i.v. cocaine self-administration by adding histamine to the cocaine solution...

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Identifiers

PMID: 23948673
DOI: 10.1016/j.physbeh.2013.08.004
PMCID: PMC4617530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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