Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences.

Psychopharmacology - 1 May 2002

Carroll Marilyn E, Morgan Andrew D, Lynch Wendy J, Campbell Una C, Dess Nancy K

Abstract excerpt

RATIONALE: Rats selectively bred for high intake of a sweet saccharin solution (HiS) consume more ethanol than their low-saccharin intake (LoS) counterparts. The HiS phenotype may be a predictor of abuse of other drugs via other routes of administration. OBJECTIVE: HiS and LoS, male and female rats were tested for acquisition of IV cocaine and heroin self-administration under a fixed-ratio 1 (FR1) schedule, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cocaine
Share to Conditioning, Operant

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drinking

Share to Eating

Share to Infusions, Intravenous

Share to Rats, Sprague-Dawley

Share to Reinforcement, Psychology

Share to Self Administration

Source

Identifiers

PMID: 12021834
DOI: 10.1007/s00213-002-1030-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences.PMID 12021834Read ↗

Escalation of intravenous cocaine self-administration, progressive-ratio performance, and reinstatement in rats selectively bred for high (HiS) and low (LoS) saccharin intake.Semantic proximity Read ↗

Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake.Semantic proximity Read ↗

Impulsivity on a Go/No-go task for intravenous cocaine or food in male and female rats selectively bred for high and low saccharin intake.Semantic proximity Read ↗

Selective breeding for differential saccharin intake as an animal model of drug abuse.Semantic proximity Read ↗

Individual difference in addiction-like behaviors and choice between cocaine versus food in Heterogeneous Stock ratsSemantic proximity Read ↗

Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: effects of saccharin preference, impulsivity, and sex.Semantic proximity Read ↗

A translational rodent model of individual differences in sensitivity to the aversive properties of ethanolSemantic proximity Read ↗

Intracranial self-stimulation reward thresholds during morphine withdrawal in rats bred for high (HiS) and low (LoS) saccharin intake.Semantic proximity Read ↗

Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaineSemantic proximity Read ↗

Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaine.Semantic proximity Read ↗

Differences between males and females in psychostimulant/sucrose self-administration (when observed) may not necessarily be driven by biological sexSemantic proximity Read ↗

Sex differences and addiction severity influence methadone, buprenorphine, and naltrexone efficacy on oxycodone motivation in genetically diverse ratSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.