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Article

Intracranial self-stimulation reward thresholds during morphine withdrawal in rats bred for high (HiS) and low (LoS) saccharin intake.

Brain research - 30 Mar 2015

Holtz Nathan A, Radke Anna K, Zlebnik Natalie E, Harris Andrew C, Carroll Marilyn E

Abstract excerpt

RATIONALE: Sweet preference is a marker of vulnerability to substance use disorders, and rats selectively bred for high (HiS) vs. low saccharin (LoS) intake display potentiated drug-seeking behaviors. Recent work indicated that LoS rats were more responsive to the negative effects of drugs in several assays. OBJECTIVE: The current study used the intracranial self-stimulation (ICSS) procedure to investigate the...

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Identifiers

PMID: 25582876
DOI: 10.1016/j.brainres.2015.01.004
PMCID: PMC4583776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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