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Article

Rap1 GTPase regulation of adherens junction positioning and cell adhesion.

Science (New York, N.Y.) - 15 Feb 2002

Knox Andrea L, Brown Nicholas H

Abstract excerpt

Cell-cell junctions are distributed evenly around the lateral circumference of cells within an epithelium. We find that the even distribution of adherens junctions is an active process that requires the small guanosine triphosphatase Rap1. Cells mutant for Rap1 condensed their adherens junctions to one side of the cell. This disrupted normal epithelial cell behavior, and mutant cell clones dispersed into the...

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Identifiers

PMID: 11847339
DOI: 10.1126/science.1067549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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