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Article

Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation.

The Journal of biological chemistry - 1 Jan 1999

Hu C D, Kariya K, Okada T, Qi X, Song C, Kataoka T

Abstract excerpt

Rap1A is phosphorylated by cAMP-dependent protein kinase (PKA), and this phosphorylation has been shown to modulate its interaction with other proteins. However, it is not known whether Rap1A phosphorylation is involved in regulation of its cellular functions, including suppression of Ras-depende...

Topics

Amino Acid Sequence
Animals
COS Cells
GTP-Binding Proteins
Molecular Sequence Data
Mutation
Phosphorylation
Protein Binding
Proto-Oncogene Proteins c-raf
Recombinant Proteins
Serine
rap GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

ras Proteins

Source

Identifiers

PMID: 9867809
DOI: 10.1074/jbc.274.1.48

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9867809-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation.PMID 9867809Read ↗

Protein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration.Semantic proximity Read ↗

Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.Semantic proximity Read ↗

Phosphorylation of rap1GAP in vivo and by cAMP-dependent kinase and the cell cycle p34cdc2 kinase in vitro.Semantic proximity Read ↗

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Phosphorylation of GTP dissociation inhibitor by PKA negatively regulates RhoA.Semantic proximity Read ↗

RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation.Semantic proximity Read ↗

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The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases.Semantic proximity Read ↗

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