Article
Minor drug-resistant HIV type-1 variants in breast milk and plasma of HIV type-1-infected Ugandan women after nevirapine single-dose prophylaxis.
Antiviral therapy - 1 Jan 2011
Pilger Daniel, Hauser Andrea, Kuecherer Claudia, Mugenyi Kizito, Kabasinguzi Rose, Somogyi Sybille, Harms Gundel, Kunz Andrea
Abstract excerpt
BACKGROUND: Nevirapine single-dose (NVP-SD) reduces mother-to-child transmission of HIV type-1 (HIV-1), but frequently induces resistance mutations in the HIV-1 genome. Little is known about drug-resistant HIV-1 variants in the breast milk of women who have taken NVP-SD. METHODS: Blood and breast milk samples of 39 HIV-1-infected Ugandan women were taken 6-12 weeks after NVP-SD intake. Samples were analysed by...
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