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Article

Genetic variations in a PTEN/AKT/mTOR axis and prostate cancer risk in a Chinese population.

PloS one - 1 Jan 2012

Chen Jiawei, Shao Pengfei, Cao Qiang, Li Pu, Li Jie, Cai Hongzhou, Zhu Jian, Wang Meilin, Zhang Zhengdong, Qin Chao, Yin Changjun

Abstract excerpt

BACKGROUND: Genetic variations in a PTEN/AKT/mTOR signaling axis may influence cellular functions including cell growth, proliferation and apoptosis, and then increase the individual's risk of cancer. Accordingly, we explore the association between single nucleotide polymorphisms (SNPs) of these genes and prostate cancer (PCa) in our Chinese population. METHODS: Subjects were recruited from 666 PCa patients and...

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Source

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Identifiers

PMID: 22815832
DOI: 10.1371/journal.pone.0040817
PMCID: PMC3399895

Genes

PTEN
AKT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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