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Article

Genetic variants in mTOR-pathway-related genes contribute to osteoarthritis susceptibility.

International immunopharmacology - 1 Dec 2019

Xu Zhonghua, Yang Haoyu, Zhou Xindie, Li Jin, Jiang Lifeng, Li Dong, Wu Lidong, Huang Yong, Xu Nanwei

Abstract excerpt

The mTOR signaling pathway has been demonstrated to be related to the development of osteoarthritis (OA) by regulating expression of autophagy regulators. Few studies have shed light on the association of mTOR-pathway-related gene variants with OA risk. Totally 441 OA patients and 533 controls were recruited and their genotypes for mTOR-pathway-related gene variants were determined based on the matrix-assisted...

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PMID: 31704287
DOI: 10.1016/j.intimp.2019.105960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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