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Article

TGFA and IRF6 contribute to the risk of nonsyndromic cleft lip with or without cleft palate in northeast China.

PloS one - 1 Jan 2013

Lu Yongping, Liu Qiang, Xu Wei, Li Zengjian, Jiang Miao, Li Xuefu, Zhao Ning, Liu Wei, Sui Yu, Ma Chao, Feng Wenhua, Han Weitian, Li Jianxin

Abstract excerpt

Nonsyndromic cleft lip with or without cleft palate (NSCL/P) are common birth defects with a complex etiology. Multiple interacting loci and possible environmental factors influence the risk of NSCL/P. 12 single nucleotide polymorphisms (SNPs) in 7 candidate genes were tested using an allele-specific primer extension for case-control and case-parent analyses in northeast China in 236 unrelated patients, 185...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23940636
DOI: 10.1371/journal.pone.0070754
PMCID: PMC3735505

Genes

TGFA
BCL3
MTHFR
SUMO1
TGFB3

Variants

rs3771494
rs3771494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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TGFA and IRF6 contribute to the risk of nonsyndromic cleft lip with or without cleft palate in northeast China.PMID 23940636Read ↗

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