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Article

Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.

PloS one - 1 Jan 2012

Letra Ariadne, Fakhouri Walid, Fonseca Renata F, Menezes Renato, Kempa Inga, Prasad Joanne L, McHenry Toby G, Lidral Andrew C, Moreno Lina, Murray Jeffrey C, Daack-Hirsch Sandra, Marazita Mary L, Castilla Eduardo E, Lace Baiba, Orioli Ieda M, Granjeiro Jose M, Schutte Brian C, Vieira Alexandre R

Abstract excerpt

Previous evidence from tooth agenesis studies suggested IRF6 and TGFA interact. Since tooth agenesis is commonly found in individuals with cleft lip/palate (CL/P), we used four large cohorts to evaluate if IRF6 and TGFA interaction contributes to CL/P. Markers within and flanking IRF6 and TGFA genes were tested using Taqman or SYBR green chemistries for case-control analyses in 1,000 Brazilian individuals. We...

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Source

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Identifiers

PMID: 23029012
DOI: 10.1371/journal.pone.0045441
PMCID: PMC3447924

Genes

TGFA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.PMID 23029012Read ↗

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