Article
Genetic effect of transforming growth factor alpha gene variants on the risk of nonsyndromic cleft lip with or without palate in korean populations.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association - 1 May 2015
Kim Bo-Mi, Kim Young Ho, Kim Dong-Hyun, Park Ji Wan, Baek Seung-Hak
Abstract excerpt
OBJECTIVE: To identify the contribution of TGFA gene variants to the risk of nonsyndromic cleft lip with or without palate (NS-CL±P). DESIGN: The samples were from 142 Korean NS-CL±P families and 119 control parents having nonaffected children. Minor allele frequency, heterozygosity, and χ(2) test for Hardy-Weinberg equilibrium were calculated for each of 10 selected single-nucleotide polymorphisms (SNPs). Ten...
Topics
- Alleles
- Case-Control Studies
- Child
- Cleft Lip
- Cleft Palate
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Haplotypes
- Humans
- Male
- Polymorphism, Single Nucleotide
- Republic of Korea