Article
Targeted re-sequencing identified rs3106189 at the 5' UTR of TAPBP and rs1052918 at the 3' UTR of TCF3 to be associated with the overall survival of colorectal cancer patients.
PloS one - 1 Jan 2013
Shao Jiaofang, Lou Xiaoyan, Wang Jun, Zhang Jing, Chen Chen, Hua Dasong, Mo Fan, Han Xu, Zheng Shu, Lin Biaoyang
Abstract excerpt
Recent studies have demonstrated the power of deep re-sequencing of the whole genome or exome in understanding cancer genomes. However, targeted capture of selected genomic whole gene-body regions, rather than the whole exome, have several advantages: 1) the genes can be selected based on biology or a hypothesis; 2) mutations in promoter and intronic regions, which have important regulatory roles, can be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.