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Article

An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2010

Flagel Shelly B, Robinson Terry E, Clark Jeremy J, Clinton Sarah M, Watson Stanley J, Seeman Phillip, Phillips Paul E M, Akil Huda

Abstract excerpt

Rats selectively bred based on high or low reactivity to a novel environment were characterized for other behavioral and neurobiological traits thought to be relevant to addiction vulnerability. The two lines of animals, which differ in their propensity to self-administer drugs, also differ in the value they attribute to cues associated with reward, in impulsive behavior, and in their dopamine system. When a cue...

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Share to Behavior, Addictive
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19794408
DOI: 10.1038/npp.2009.142
PMCID: PMC2794950

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