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Article

An intersubunit zinc binding site in rat P2X2 receptors.

The Journal of biological chemistry - 15 Jul 2005

Nagaya Naomi, Tittle Rachel K, Saar Nir, Dellal Shlomo S, Hume Richard I

Abstract excerpt

P2X receptors are ATP-gated ion channels made up of three similar or identical subunits. It is unknown whether ligand binding is intersubunit or intrasubunit, either for agonists or for allosteric modulators. Zinc binds to rat P2X2 receptors and acts as an allosteric modulator, potentiating channel opening. To probe the location of this zinc binding site, P2X2 receptors bearing mutations of the histidines at...

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Identifiers

PMID: 15899882
DOI: 10.1074/jbc.M504545200
PMCID: PMC1479454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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