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Article

Mechanisms of protein sequence divergence and incompatibility.

PLoS genetics - 1 Jan 2013

Wellner Alon, Raitses Gurevich Maria, Tawfik Dan S

Abstract excerpt

Alignments of orthologous protein sequences convey a complex picture. Some positions are utterly conserved whilst others have diverged to variable degrees. Amongst the latter, many are non-exchangeable between extant sequences. How do functionally critical and highly conserved residues diverge? Why and how did these exchanges become incompatible within contemporary sequences? Our model is phosphoglycerate kinase...

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Identifiers

PMID: 23935519
DOI: 10.1371/journal.pgen.1003665
PMCID: PMC3723536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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