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Article

The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.

G3 (Bethesda, Md.) - 3 Oct 2013

DaSilva Lance F, Pillon Samantha, Genereaux Julie, Davey Megan J, Gloor Gregory B, Karagiannis Jim, Brandl Christopher J

Abstract excerpt

Mec1, a member of the phosphoinositide three-kinase-related kinase (PIKK) family of proteins, is involved in the response to replicative stress and DNA damage and in telomere maintenance. An essential 30 to 35 residue, the FATC domain is found at the C-terminus of all PIKK family members. To inve...

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Identifiers

PMID: 23934994
DOI: 10.1534/g3.113.006841
PMCID: PMC3789791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23934994-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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