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Article

A novel approach to estimating heterozygosity from low-coverage genome sequence.

Genetics - 1 Oct 2013

Bryc Katarzyna, Patterson Nick, Reich David

Abstract excerpt

High-throughput shotgun sequence data make it possible in principle to accurately estimate population genetic parameters without confounding by SNP ascertainment bias. One such statistic of interest is the proportion of heterozygous sites within an individual's genome, which is informative about inbreeding and effective population size. However, in many cases, the available sequence data of an individual are...

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Identifiers

PMID: 23934885
DOI: 10.1534/genetics.113.154500
PMCID: PMC3781980

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