Article
A test for genetic association that incorporates information about deviation from Hardy-Weinberg proportions in cases.
American journal of human genetics - 1 Jul 2008
Wang Jian, Shete Sanjay
Abstract excerpt
For assessment of genetic association between single-nucleotide polymorphisms (SNPs) and disease status, the logistic-regression model or generalized linear model is typically employed. However, testing for deviation from Hardy-Weinberg proportion in a patient group could be another approach for genetic-association studies. The Hardy-Weinberg proportion is one of the most important principles in population...
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