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Article

Alterations in the EGFR pathway coincide in colorectal cancer and impact on prognosis.

Virchows Archiv : an international journal of pathology - 1 Oct 2013

Neumann Jens, Wehweck Laura, Maatz Susanne, Engel Jutta, Kirchner Thomas, Jung Andreas

Abstract excerpt

Alterations of the downstream effectors of the epidermal growth factor receptor (EGFR) are common events in colorectal cancer (CRC) carcinogenesis. Since EGFR serves as a target for therapy and some downstream effectors of EGFR have predictive and prognostic impact, reliable information on the frequency and concordance of alterations in the signaling pathway has become clinically significant. We, therefore,...

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Source

Identifiers

PMID: 23934607
DOI: 10.1007/s00428-013-1450-0

Genes

EGFR
BRAF
KRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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