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Article

Paired Primary and Metastatic Tumor Analysis of Somatic Mutations in Synchronous and Metachronous Colorectal Cancer.

Cancer research and treatment - 1 Jan 2017

Kim Kyu-Pyo, Kim Jeong-Eun, Hong Yong Sang, Ahn Sung-Min, Chun Sung Min, Hong Seung-Mo, Jang Se Jin, Yu Chang Sik, Kim Jin Cheon, Kim Tae Won

Abstract excerpt

PURPOSE: Although the mutation status of KRAS is highly concordant in primary and metastatic lesions, it has not been generalized to other major pathway genes. MATERIALS AND METHODS: In this study, 41 genes were evaluated and the mutational profiles were compared in 46 colorectal cancer patients with paired surgical specimens of primary and metastatic lesions: synchronous (n=27) and metachronous (n=19) lesions. A...

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Source

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Identifiers

PMID: 27384156
DOI: 10.4143/crt.2015.490
PMCID: PMC5266409

Genes

KRAS
APC
BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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