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Article

Apolipoprotein E gene polymorphism influences aggressive behavior in prostate cancer cells by deregulating cholesterol homeostasis.

International journal of oncology - 1 Oct 2013

Ifere Godwin O, Desmond Renee, Demark-Wahnefried Wendy, Nagy Tim R

Abstract excerpt

High circulating cholesterol and its deregulated homeostasis may facilitate prostate cancer progression. Genetic polymorphism in Apolipoprotein (Apo) E, a key cholesterol regulatory protein may effect changes in systemic cholesterol levels. In this investigation, we determined whether variants of the Apo E gene can trigger defective intracellular cholesterol efflux, which could promote aggressive prostate cancer....

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Identifiers

PMID: 23934233
DOI: 10.3892/ijo.2013.2057
PMCID: PMC3829771

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