Article
E-cadherin promoter polymorphisms are not associated with the aggressiveness of prostate cancer in Caucasian patients.
Urologic oncology - 1 Jan 2000
Li He-Cheng, Albert Jeffrey M, Shinohara Eric T, Cai Qiuyin, Freyer Andrea, Cai Hui, Cao Carolyn, Wang Zuofei, Kataoka Nobuhiko, Teng Ming, Zheng Wei, Lu Bo
Abstract excerpt
BACKGROUND: -160C-->A and -347G-->GA polymorphisms in the promoter region decrease E-cadherin gene transcription. Decreased E-cadherin expression predicts poor outcome among patients with cancer. We sought to investigate whether -160C-->A and/or -347G-->GA polymorphisms were associated with the aggressiveness of prostate cancer. METHODS: TaqMan single nucleotide polymorphism genotyping assay (Applied Biosystems,...
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