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Article

Single-nucleotide polymorphisms within the antioxidant defence system and associations with aggressive prostate cancer.

BJU international - 1 Jan 2011

Abe Miyako, Xie Wanling, Regan Meredith M, King Irena B, Stampfer Meir J, Kantoff Philip W, Oh William K, Chan June M

Abstract excerpt

OBJECTIVE: To study the effects of oxidative stress on prostate cancer development as the exact biological mechanisms behind the relationship remain uncertain. We previously reported a statistically significant interaction between circulating selenium levels, variants in the superoxide dismutase 2 gene (SOD2; rs4880), and risk of developing prostate cancer and presenting with aggressive prostate cancer. PATIENTS...

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Source

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Identifiers

PMID: 20477822
DOI: 10.1111/j.1464-410X.2010.09344.x
PMCID: PMC3010266

Genes

SOD2
SOD1
GPX1
GPX4
SOD3
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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