Article
cMYC expression in infiltrating gliomas: associations with IDH1 mutations, clinicopathologic features and outcome.
Journal of neuro-oncology - 1 Nov 2013
Odia Yazmin, Orr Brent A, Bell W Robert, Eberhart Charles G, Rodriguez Fausto J
Abstract excerpt
Gliomas are among the most frequent adult primary brain tumors. Mutations in IDH1, a metabolic enzyme, strongly correlate with secondary glioblastomas and increased survival. cMYC is an oncogene also implicated in aberrant metabolism, but its prognostic impact remains unclear. Recent genotyping s...
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