Article
Prognostic stratification of gliomatosis cerebri by IDH1 R132H and INA expression.
Journal of neuro-oncology - 1 Nov 2011
Desestret Virginie, Ciccarino Pietro, Ducray François, Crinière Emmanuelle, Boisselier Blandine, Labussière Marianne, Polivka Marc, Idbaih Ahmed, Kaloshi Gentian, von Deimling Andreas, Hoang-Xuan Khe, Delattre Jean-Yves, Mokhtari Karima, Sanson Marc
Abstract excerpt
Gliomatosis cerebri (GC) constitutes a heterogeneous group of conditions involving diffuse neoplastic glial cell infiltration of the brain. Management is difficult and an obvious challenge is to identify prognostic factors. Alpha-internexin (INA) expression, which is closely related to the 1p19q codeletion, is a strong prognostic marker in oligodendroglial tumors. Similarly, the R132H isocitrate dehydrogenase 1...
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