Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation.

Nature structural & molecular biology - 1 Sept 2013

Delvecchio Manuela, Gaucher Jonathan, Aguilar-Gurrieri Carmen, Ortega Esther, Panne Daniel

Abstract excerpt

CBP and p300 are histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. Mutations in their catalytic 'cores' are linked to genetic disorders, including cancer. Here we present the 2.8-Å crystal structure of the catalytic core of human p300 co...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to Chromatin
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Stability

Share to p300-CBP Transcription Factors

Share to Protein Interaction Domains and Motifs

Share to Recombinant Fusion Proteins

Share to Substrate Specificity

Source

Identifiers

PMID: 23934153
DOI: 10.1038/nsmb.2642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23934153-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation.PMID 23934153Read ↗

Dysregulation of the p300/CBP histone acetyltransferases in human cancer.Semantic proximity Read ↗

p300/CBP proteins: HATs for transcriptional bridges and scaffoldsSemantic proximity Read ↗

Structural insights into p300 regulation and acetylation-dependent genome organisationSemantic proximity Read ↗

Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth.Semantic proximity Read ↗

Is histone acetylation the most important physiological function for CBP and p300?Semantic proximity Read ↗

Genetic mutations and inhibitors of p300 and CBP.Semantic proximity Read ↗

The PHD type zinc finger is an integral part of the CBP acetyltransferase domain.Semantic proximity Read ↗

Life and death of transcriptional co-activator p300Semantic proximity Read ↗

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.Semantic proximity Read ↗

Structural insights into human KAP1 PHD finger–bromodomain and its role in gene silencingSemantic proximity Read ↗

Structure of the PRC2 complex and application to drug discovery.Semantic proximity Read ↗

Menke-Hennekam syndrome; delineation of domain-specific subtypes with distinct clinical and DNA methylation profiles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.