Article
Genome-Wide Association Study in Asians Identifies Novel Loci for High Myopia and Highlights a Nervous System Role in Its Pathogenesis.
Ophthalmology - 1 Dec 2020
Meguro Akira, Yamane Takahiro, Takeuchi Masaki, Miyake Masahiro, Fan Qiao, Zhao Wanting, Wang I-Jong, Mizuki Yuki, Yamada Norihiro, Nomura Naoko, Tsujikawa Akitaka, Matsuda Fumihiko, Hosoda Yoshikatsu, Saw Seang-Mei, Cheng Ching-Yu, Tsai Tzu-Hsun, Yoshida Masao, Iijima Yasuhito, Teshigawara Takeshi, Okada Eiichi, Ota Masao, Inoko Hidetoshi, Mizuki Nobuhisa
Abstract excerpt
PURPOSE: To identify novel susceptibility loci for high myopia. DESIGN: Genome-wide association study (GWAS) followed by replication and meta-analysis. PARTICIPANTS: A total of 14 096 samples from East and Southeast Asian populations (2549 patients with high myopia and 11 547 healthy controls). METHODS: We performed a GWAS in 3269 Japanese individuals (1668 with high myopia and 1601 control participants),...
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