Article
Genome-wide association study of lung function phenotypes in a founder population.
The Journal of allergy and clinical immunology - 1 Jan 2014
Yao Tsung-Chieh, Du Gaixin, Han Lide, Sun Ying, Hu Donglei, Yang James J, Mathias Rasika, Roth Lindsey A, Rafaels Nicholas, Thompson Emma E, Loisel Dagan A, Anderson Rebecca, Eng Celeste, Arruabarrena Orbegozo Maitane, Young Melody, Klocksieben James M, Anderson Elizabeth, Shanovich Kathleen, Lester Lucille A, Williams L Keoki, Barnes Kathleen C, Burchard Esteban G, Nicolae Dan L, Abney Mark, Ober Carole
Abstract excerpt
BACKGROUND: Lung function is a long-term predictor of mortality and morbidity. OBJECTIVE: We sought to identify single nucleotide polymorphisms (SNPs) associated with lung function. METHODS: We performed a genome-wide association study (GWAS) of FEV1, forced vital capacity (FVC), and FEV1/FVC in 1144 Hutterites aged 6 to 89 years, who are members of a founder population of European descent. We performed least...
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